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In pharmaceutical manufacturing facilities, high humidity causes fine powders to adsorb moisture, clogging the powder feed to the tableting press. Powder inconsistency caused by moisture adsorption results in crumbling tablets and clogged tablet dies. Variations in humidity mean difficult adjustments in bed temperature and spraying rates, resulting in heat damage and moisture intrusion. Humidity in air ductwork creates moist places for bacterial colonies to grow and cause process contamination. Two common approaches to humidity control are air conditioning and desiccants. Air conditioning lowers the temperature of a surface exposed to the clean room airstream below the dew point of that airstream. Excess water vapor condenses and the resulting air is dehumidified. The air must then be reheated to the proper control temperature and routed to the clean room. Standard refrigeration equipment can produce dew points of +40°F (4°C) on a reliable basis. In a desiccant system, the process airstream passes through a desiccant medium. The desiccant adsorbs moisture directly from the airstream, and the resulting dehumidified air is routed to the clean room. Desiccant dehumidifiers can produce dew points below 0°F (-18°C), a fivefold reduction in the air moisture beyond what can be achieved with standard HVAC-grade refrigeration systems.
The MMR 31 can be ordered with either one or two outputs. This information could be used as feedback to the process control or the HVAC system to optimize the clean room environmental parameters. The alarm contacts of either analyzer may be set for relative humidity and temperature to indicate a system malfunction or warn of a condition that could be detrimental to production.
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