{"id":10454,"date":"2019-09-27T13:53:20","date_gmt":"2019-09-27T19:53:20","guid":{"rendered":"https:\/\/www.coleparmer.com\/blog\/?p=10454"},"modified":"2019-10-24T08:14:51","modified_gmt":"2019-10-24T14:14:51","slug":"process-connections-comply-industry-standards","status":"publish","type":"post","link":"https:\/\/www.coleparmer.com\/blog\/process-connections-comply-industry-standards\/","title":{"rendered":"Do your Process Connections Comply with Industry Standards?"},"content":{"rendered":"<p>by Mary Vessele, Product Marketing Manager, Test &amp; Measurement<\/p>\n<h2>Sanitary connections are critical for a contamination-free process<\/h2>\n<p>In the pharmaceutical, food &amp; beverage, and biotech industries, contamination-free processing is critical. The integrity of the sanitary manufacturing application is essential for full compliance with the validation process.<\/p>\n<p>The potential for contamination increases with the introduction of peripheral components, such as filtration and temperature and pressure measuring instrumentation required to ensure process parameters remain within acceptable limits. As a result, these inline devices must themselves meet standards set by governing agencies to ensure there are no weak links in the sanitary chain.<\/p>\n<h2>Organizations providing sanitary requirements<\/h2>\n<p>There are many organizations that outline the standards needed to adhere to the sanitary requirements in a validated environment. The following organizations offer guidelines: 3<strong>A<\/strong>\u20143A Sanitary Standards, Inc. (3A SSI), <strong>USP Class IV,<\/strong> <strong>FDA Compliant,<\/strong> <strong>cGMP<\/strong>\u2014current Good Manufacturing Practices, and\u00a0<strong>EHEDG-Certified<\/strong>\u2014The European Hygienic Engineering &amp; Design Group.<\/p>\n<p>Sanitary connections must meet USDA or FDA requirements, or meet 3A sanitary standards, for a process system to be eligible for validation. The standards make recommendations on what type of process connection should be used.\u00a0 Available sanitary connections include Tri-Clover\u00ae Tri-Clamp\u00ae, Cherry-Burrell\u00ae, DIN 11851, DIN 32676, ISO 2852, Varivent\u00ae, and 4\u201d Tank Spud, among others.<\/p>\n<h2>Connection materials matter<\/h2>\n<p>You will also need to take into consideration the type of materials the connection is made from. Austenitic stainless steel is used as the standard material for sanitary applications. 316L stainless steel is the most common. This material provides good welding and corrosion-resistance attributes. To add to the list of considerations, the surface finish may need to be Ra&lt;=15 \u00b5in electro polished depending on the application as the process wetted surfaces and anything that comes in contact with the media needs to be passive and free of microscopic faults to avoid buildup of pathogenic organisms and\/or the formation of biofilms. The considerations when choosing a process connection does not stop here. You also need to think about the gauge casing material, instrument housing, autoclave sterilization, diaphragm seals, the list goes on and on.<\/p>\n<p>With all of the different governing bodies offering advice on how to adhere to a hygienic environment and all of the different types of hygienic connections available, I thought it might be helpful to recommend a technical resource to help you make the correct choices for hygienic process needs. Not only does Cole-Parmer offer an extensive line of hygienic and non-hygienic process connections, but we have the technical knowledge to guide your decisions. Read the entire <a title=\"Sanitary Instrumentation Primer\" href=\"\/tech-article\/sanitary-instrumentation-primer\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">sanitary instrumentation article<\/a>.<\/p>\n<p><a title=\"Pressure Products\" href=\"\/c\/pressure-and-vacuum-instruments\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">Shop all pressure products<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>by Mary Vessele, Product Marketing Manager, Test &amp; Measurement Sanitary connections are critical for a contamination-free process In the pharmaceutical, food &amp; beverage, and biotech industries, contamination-free processing is critical. The integrity of the sanitary&#8230;<\/p>\n","protected":false},"author":20,"featured_media":10461,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-10454","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-process-2"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Do your Process Connections Comply with Industry Standards? | Cole-Parmer Blog<\/title>\n<meta name=\"description\" content=\"In the pharma, food &amp; beverage, and biotech industries, contamination-free processing is critical. Your sanitary connections are critical for a contamination-free process\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.coleparmer.de\/blog\/process-connections-comply-industry-standards\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Do your Process Connections Comply with Industry Standards? | Cole-Parmer Blog\" \/>\n<meta property=\"og:description\" content=\"In the pharma, food &amp; beverage, and biotech industries, contamination-free processing is critical. Your sanitary connections are critical for a contamination-free process\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.coleparmer.de\/blog\/process-connections-comply-industry-standards\/\" \/>\n<meta property=\"og:site_name\" content=\"Cole-Parmer Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/antylia\" \/>\n<meta property=\"article:published_time\" content=\"2019-09-27T19:53:20+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-10-24T14:14:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/i0.wp.com\/www.coleparmer.de\/blog\/wp-content\/uploads\/2019\/09\/ashcroft-ashcroft-sanitary-pressure-gauges-3-4-tri-clamp-52435.jpg?fit=300%2C300&ssl=1\" \/>\n\t<meta property=\"og:image:width\" content=\"300\" \/>\n\t<meta property=\"og:image:height\" content=\"300\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Cole-Parmer Blog Team\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@antylia\" \/>\n<meta name=\"twitter:site\" content=\"@antylia\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Cole-Parmer Blog Team\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Do your Process Connections Comply with Industry Standards? | Cole-Parmer Blog","description":"In the pharma, food & beverage, and biotech industries, contamination-free processing is critical. Your sanitary connections are critical for a contamination-free process","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.coleparmer.de\/blog\/process-connections-comply-industry-standards\/","og_locale":"en_US","og_type":"article","og_title":"Do your Process Connections Comply with Industry Standards? | Cole-Parmer Blog","og_description":"In the pharma, food & beverage, and biotech industries, contamination-free processing is critical. Your sanitary connections are critical for a contamination-free process","og_url":"https:\/\/www.coleparmer.de\/blog\/process-connections-comply-industry-standards\/","og_site_name":"Cole-Parmer Blog","article_publisher":"https:\/\/www.facebook.com\/antylia","article_published_time":"2019-09-27T19:53:20+00:00","article_modified_time":"2019-10-24T14:14:51+00:00","og_image":[{"width":300,"height":300,"url":"https:\/\/i0.wp.com\/www.coleparmer.de\/blog\/wp-content\/uploads\/2019\/09\/ashcroft-ashcroft-sanitary-pressure-gauges-3-4-tri-clamp-52435.jpg?fit=300%2C300&ssl=1","type":"image\/jpeg"}],"author":"Cole-Parmer Blog Team","twitter_card":"summary_large_image","twitter_creator":"@antylia","twitter_site":"@antylia","twitter_misc":{"Written by":"Cole-Parmer Blog Team","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.coleparmer.de\/blog\/process-connections-comply-industry-standards\/#article","isPartOf":{"@id":"https:\/\/www.coleparmer.de\/blog\/process-connections-comply-industry-standards\/"},"author":{"name":"Cole-Parmer Blog Team","@id":"https:\/\/www.coleparmer.com\/blog\/#\/schema\/person\/bd8d004d4d77d6b31800fa11177c6da9"},"headline":"Do your Process Connections Comply with Industry Standards?","datePublished":"2019-09-27T19:53:20+00:00","dateModified":"2019-10-24T14:14:51+00:00","mainEntityOfPage":{"@id":"https:\/\/www.coleparmer.de\/blog\/process-connections-comply-industry-standards\/"},"wordCount":434,"commentCount":0,"publisher":{"@id":"https:\/\/www.coleparmer.com\/blog\/#organization"},"image":{"@id":"https:\/\/www.coleparmer.de\/blog\/process-connections-comply-industry-standards\/#primaryimage"},"thumbnailUrl":"https:\/\/www.coleparmer.com\/blog\/wp-content\/uploads\/2019\/09\/ashcroft-ashcroft-sanitary-pressure-gauges-3-4-tri-clamp-52435.jpg","articleSection":["Process"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.coleparmer.de\/blog\/process-connections-comply-industry-standards\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.coleparmer.de\/blog\/process-connections-comply-industry-standards\/","url":"https:\/\/www.coleparmer.de\/blog\/process-connections-comply-industry-standards\/","name":"Do your Process Connections Comply with Industry Standards? | Cole-Parmer Blog","isPartOf":{"@id":"https:\/\/www.coleparmer.com\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.coleparmer.de\/blog\/process-connections-comply-industry-standards\/#primaryimage"},"image":{"@id":"https:\/\/www.coleparmer.de\/blog\/process-connections-comply-industry-standards\/#primaryimage"},"thumbnailUrl":"https:\/\/www.coleparmer.com\/blog\/wp-content\/uploads\/2019\/09\/ashcroft-ashcroft-sanitary-pressure-gauges-3-4-tri-clamp-52435.jpg","datePublished":"2019-09-27T19:53:20+00:00","dateModified":"2019-10-24T14:14:51+00:00","description":"In the pharma, food & beverage, and biotech industries, contamination-free processing is critical. Your sanitary connections are critical for a contamination-free process","breadcrumb":{"@id":"https:\/\/www.coleparmer.de\/blog\/process-connections-comply-industry-standards\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.coleparmer.de\/blog\/process-connections-comply-industry-standards\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.coleparmer.de\/blog\/process-connections-comply-industry-standards\/#primaryimage","url":"https:\/\/www.coleparmer.com\/blog\/wp-content\/uploads\/2019\/09\/ashcroft-ashcroft-sanitary-pressure-gauges-3-4-tri-clamp-52435.jpg","contentUrl":"https:\/\/www.coleparmer.com\/blog\/wp-content\/uploads\/2019\/09\/ashcroft-ashcroft-sanitary-pressure-gauges-3-4-tri-clamp-52435.jpg","width":300,"height":300,"caption":"pressure gage"},{"@type":"BreadcrumbList","@id":"https:\/\/www.coleparmer.de\/blog\/process-connections-comply-industry-standards\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.coleparmer.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Do your Process Connections Comply with Industry Standards?"}]},{"@type":"WebSite","@id":"https:\/\/www.coleparmer.com\/blog\/#website","url":"https:\/\/www.coleparmer.com\/blog\/","name":"Cole-Parmer Blog","description":"","publisher":{"@id":"https:\/\/www.coleparmer.com\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.coleparmer.com\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.coleparmer.com\/blog\/#organization","name":"Antylia Scientific","url":"https:\/\/www.coleparmer.com\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.coleparmer.com\/blog\/#\/schema\/logo\/image\/","url":"https:\/\/i0.wp.com\/www.coleparmer.co.uk\/blog\/wp-content\/uploads\/2021\/02\/AntyliaScientific_CMYK.jpg?fit=400%2C107&ssl=1","contentUrl":"https:\/\/i0.wp.com\/www.coleparmer.co.uk\/blog\/wp-content\/uploads\/2021\/02\/AntyliaScientific_CMYK.jpg?fit=400%2C107&ssl=1","width":400,"height":107,"caption":"Antylia Scientific"},"image":{"@id":"https:\/\/www.coleparmer.com\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/antylia","https:\/\/x.com\/antylia","https:\/\/www.linkedin.com\/company\/antylia\/","https:\/\/www.youtube.com\/channel\/UC41i86hGEGhQhM1KMqrDnZg"]},{"@type":"Person","@id":"https:\/\/www.coleparmer.com\/blog\/#\/schema\/person\/bd8d004d4d77d6b31800fa11177c6da9","name":"Cole-Parmer Blog Team","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.coleparmer.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/34e3e6aa661d0e443fb9050a9175a092?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/34e3e6aa661d0e443fb9050a9175a092?s=96&d=mm&r=g","caption":"Cole-Parmer Blog Team"},"url":"https:\/\/www.coleparmer.com\/blog\/author\/donna-donahue\/"}]}},"_links":{"self":[{"href":"https:\/\/www.coleparmer.com\/blog\/wp-json\/wp\/v2\/posts\/10454","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.coleparmer.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.coleparmer.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.coleparmer.com\/blog\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/www.coleparmer.com\/blog\/wp-json\/wp\/v2\/comments?post=10454"}],"version-history":[{"count":8,"href":"https:\/\/www.coleparmer.com\/blog\/wp-json\/wp\/v2\/posts\/10454\/revisions"}],"predecessor-version":[{"id":10564,"href":"https:\/\/www.coleparmer.com\/blog\/wp-json\/wp\/v2\/posts\/10454\/revisions\/10564"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.coleparmer.com\/blog\/wp-json\/wp\/v2\/media\/10461"}],"wp:attachment":[{"href":"https:\/\/www.coleparmer.com\/blog\/wp-json\/wp\/v2\/media?parent=10454"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.coleparmer.com\/blog\/wp-json\/wp\/v2\/categories?post=10454"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.coleparmer.com\/blog\/wp-json\/wp\/v2\/tags?post=10454"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}