{"id":11025,"date":"2020-04-09T12:17:23","date_gmt":"2020-04-09T18:17:23","guid":{"rendered":"https:\/\/www.coleparmer.com\/blog\/?p=11025"},"modified":"2020-06-11T09:27:29","modified_gmt":"2020-06-11T15:27:29","slug":"vaccines-pathogens-work-against-disease","status":"publish","type":"post","link":"https:\/\/www.coleparmer.com\/blog\/vaccines-pathogens-work-against-disease\/","title":{"rendered":"Vaccines: How Pathogens Work Against Disease"},"content":{"rendered":"<div>\n<div>By Ayisha Malik, Marketing Content Specialist<\/div>\n<div><\/div>\n<div>\n<div><strong>Vaccine development has played a huge role in shaping society as we know it today.<\/strong> The notion of acquired immunity was discovered in ancient China many centuries ago, but it wasn\u2019t until the English Scientist, Edward Jenner, developed a vaccine for smallpox using cowpox particles in the 18<sup>th<\/sup> century that the modern concept of vaccination was born. Today the vaccine industry is a global enterprise worth over USD $50 billion.\n<h2>How vaccines work<\/h2>\n<p>The concept behind vaccines is simple; a weakened pathogen used to mount an immune response needed to fight the same disease next time. Thanks to immunisation practices, infectious diseases like polio and smallpox that once obliterated communities have almost been eradicated. Many others like\u00a0measles, mumps, and\u00a0whooping cough, are also under control.<\/p>\n<h2>Development journey of a vaccine<\/h2>\n<p><img decoding=\"async\" style=\"padding: 10px;\" title=\"The Development of a Vaccine\" src=\"\/\/cms-resources.coleparmer.com\/t\/Vaccine-2-ta.jpg\" alt=\"vaccine preparation development\"><\/p>\n<p>The journey of<a title=\"Vaccine Research &amp; Development\" href=\"\/industry\/vaccine-research-and-development\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"> vaccine development <\/a>begins with identifying the disease-causing agent that scientists can manipulate to develop Live Attenuated Vaccines or Inactivated Vaccines. Genetic engineering technologies can also be used to develop modified versions.<\/p>\n<p>While the antigens in vaccine formulations evoke the immune response, without adjuvants, emulsifiers and stabilisers vaccines would not work.<\/p>\n<h2>Quality control and regulation<\/h2>\n<p>As a biological product, vaccines require special quality control (QC) and quality assurance (QA) mechanisms to ensure their safety. Global guidelines exist to ensure standards, while several <em>in vitro<\/em> and <em>in vivo <\/em>tests determine the quality and potency of finished products.<\/p>\n<p>Every vaccine has to clear pre-clinical and clinical trials before it can be licensed for use and sale. However, manufacturers can carry out additional tests to continue monitoring safety, efficacy, and other potential uses for the product.<br>\n<img decoding=\"async\" style=\"float: right; padding: 10px;\" title=\"cold chain monitoring\" src=\"\/\/cms-resources.coleparmer.com\/t\/Vaccine-4-process-ta-reduce.jpg\" alt=\"cold chain temperature monitoring\"><\/p>\n<h2>Storage and transport<\/h2>\n<p>Vaccines naturally biodegrade over time and can lose their effectiveness faster if they become too hot or cold. If stored or transported outside of <a title=\"Cold Chain\" href=\"\/industry\/cold-chain\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">cold chain<\/a> temperatures, vaccines also lose their product license and can no longer be used. Today, with <a title=\"Traceable Remote Monitoring\" href=\"\/traceablelive\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">advanced instrumentation<\/a> it is possible to better monitor and maintain temperature control \u2013 enhancing safety and traceability.<\/p>\n<h2>Summary<\/h2>\n<p>Immunisation is one of modern medicine\u2019s greatest success stories; it not only prevents sickness and death but also holds up broader gains in education and economic development all over the world.<\/p>\n<p>Read the <a title=\"Vaccines - Pathogens Fighting Disease\" href=\"\/tech-article\/vaccine-pathogens-fighting-disease\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">complete article.<\/a><\/p>\n<\/div>\n<p>For any queries and product needs for vaccine development, please\u00a0<a title=\"Contact Cole-Parmer\" href=\"\/contact-us\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><strong>contact<\/strong><\/a>\u00a0a Cole-Parmer representative in your region.<\/p>\n<h2 style=\"text-align: center;\">Get the latest blog posts delivered to your email.<\/h2>\n<h2 style=\"text-align: center;\"><strong><a href=\"\/blog\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">Sign up for our blog!<\/a><\/strong><\/h2>\n<p>\u00a0<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>By Ayisha Malik, Marketing Content Specialist Vaccine development has played a huge role in shaping society as we know it today. The notion of acquired immunity was discovered in ancient China many centuries ago, but&#8230;<\/p>\n","protected":false},"author":20,"featured_media":11029,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1981,21,1973,1983],"tags":[],"class_list":["post-11025","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cold-chain","category-temperaturehumidity","category-traceablelive","category-vaccines"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Vaccines: How pathogens work against disease | Cole-Parmer Blog<\/title>\n<meta name=\"description\" content=\"Vaccine development has played a huge role in shaping society as we know it today. 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