The Orochem 96-well filter plate is an apparatus for high-throughput filtration of cell lysates. The clarification of cell requires separation of cell debris, colloids, insoluble precipitates, aggregates and other contaminants before the target molecule is isolated and characterized. Each well contains integrated prefilters for efficient clarification of cell lysates. This plate is a depth microfiltration system that consists of a filter with an open-pore structure to remove cells and cell debris and a filter aid material with a tighter pore structure to remove colloidal matter simultaneously to deliver particulate-free feed for down-stream processes.

Each well comprises an upper filtration zone, a lower filtration zone, and a conical flow director zone. The upper filtration zone comprises an upper collection zone, a depth filter media zone, and a deep bed filtration zone. The lower filtration zone comprises the retainer ring and a supported membrane.